منابع مشابه
Sodium Channel Gating No Margin for Error
Voltage-gated Na(+) channels are the workhorses of spike generation and propagation in excitable cells. Mutations in Na(+) channel genes have been identified in disorders causing episodic dysfunction of heart, skeletal muscle, and brain. Lossin and colleagues from Al George's lab report in this issue of Neuron that three missense mutations of SCN1A found in a dominant epilepsy syndrome disrupt ...
متن کاملGating of the Bacterial Sodium Channel, NaChBac
The bacterial sodium channel, NaChBac, from Bacillus halodurans provides an excellent model to study structure-function relationships of voltage-gated ion channels. It can be expressed in mammalian cells for functional studies as well as in bacterial cultures as starting material for protein purification for fine biochemical and biophysical studies. Macroscopic functional properties of NaChBac ...
متن کاملStochastic description of sodium channel gating.
A stochastic model of the sodium channel is proposed. Transitions from the resting to the open state of the channel is described by the gamma distribution. The open state is temporary with an average open time T, and the channel proceeds to the inactivated state. The channel can be represented by two identical control molecules which undergo conformation transitions under changes of the electri...
متن کاملTheoretical implication of liganding reactions in axonal sodium channel gating.
Mathematical simulation models for measured permeability properties of axonal Na(+) channels point to the presence of bimolecular, as well as net-membrane-field-dependent intramolecular, reaction steps in channel gating reactions. An abstract chemical reaction model is presented, which postulates ligand binding reactions in both Na(+) channel activation and subsequent desensitization as observe...
متن کاملThe cardiac sodium channel: gating function and molecular pharmacology.
Cardiac sodium (Na) channels are dynamic molecules that undergo rapid structural changes in response to the changing electrical field in the myocardium. Inherited mutations in SCN5A, the gene encoding the cardiac Na channel, provoke life-threatening cardiac arrhythmias, often by modifying these voltage-dependent conformational changes. These disorders (i.e. the long QT syndrome and Brugada synd...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2002
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(02)00735-3